Its efficacy stems from the modulation of multiple signaling pathways related to oxidative stress and cell survival
doi:10.1146/annurev.bi.52.070183.003431 Mezzetti F, Vero L de, Giudici P (2014) Evolved Saccharomyces cerevisiae wine strains with enhanced glutathione production obtained by an evolution-based strategy
BAX channel activity mediates lysosomal disruption linked to Parkinson disease
These strategies may modulate neutrophil behavior (activation, recruitment, migration, infiltration), reduce NETs production, boost phagocytosis, and thus, prevent and treat CVDs (Figure 3)
Nrf2 regulates important genes such as heme-oxygenase 1(HO-1), glutathione S-transferase (GST), glutathione reductase (GR), glutamate-cysteine ligase subunits (GCLc and GCLm), NAD(P)H quinone oxidoreductase-1 (NQO1), and thioredoxins (TrxR1), among others
Mater 30 (3), 1907066