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Elevated levels of MTA and SAMe are tightly linked to T-cell exhaustion in hepatocellular carcinoma (HCC), and deletion of a key SAMe-producing enzyme MAT2A results in inhibition of T-cell exhaustion and limitation of HCC growth in mice (86)

Dionsio, F., et al

Contraindications: Not for use in individuals with cancer, during pregnancy/breastfeeding, or those under 18

After centrifugation, protein extracts were collected and 50 g of protein lysates were resolved by SDS-PAGE and electrophoretically transferred onto Immobilon-P membranes (0.22 M

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