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Blocking FOXO4, which inhibits the activation of P53, causes senescent cells to undergo apoptosis by P53 activation, without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer

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doi:10.1055/s-0037-1615780

Recent research has shown that tumor-associated fibroblasts (CAFs) contain higher levels of Ubiquitin-specific protease-7 (USP7), which promotes the deubiquitination of miRNA sort-related protein hnRNPA1

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