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In the presence of environmental toxins, gut microbiota-derived metabolites (such as glycochenodeoxycholate) can induce ferroptosis, lipid metabolic disorders, and inflammation by activating the TFR and ACSL4 [83]
Serotonin reduces glucose and increases insulin and GLP-1 secretion
metformin, sulfonylureas, TZDs, etc.) address only one of the underlying pathophysiology - lowering postprandial glucose levels, but their safety profiles and side effects, such as weight gain and hypoglycemia, may present challenges and limitations in their clinical use
The article says GLP-1 medications already demand careful fluid intake, while flu adds fluid loss and reduced oral intake on top of that, creating what it calls compounding dehydration risk
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