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Description

One study reported that somatostatin does not suppress insulin secretion by acting on the central nervous system but acts peripherally on islet beta-cells

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This is clinically important because a physiological pulse pattern does not produce the receptor desensitization or side effect profile associated with direct GH injection

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From 2 mg, increase to 4 mg

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A 2021 study in published in NEJM of obese adults that used once-weekly injections found weight loss by 10% or more

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