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The receptor-selective offshoot of this research program is setmelanotide (Rhythm Pharmaceuticals), an MC4R-selective agonist approved by FDA in 2020 for chronic body-mass control in patients with proopiomelanocortin (POMC) deficiency, leptin receptor (LEPR) deficiency, and Bardet-Biedl syndrome

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GLP mimetics are currently widely used in the treatment of Type 2 diabetes while both physiological and pathophysiological effects on the exocrine pancreas are less clear