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In middle cerebral artery occlusion (MCAO) models, treatment with exogenous LXA4 provides robust neuroprotection against IRI, markedly decreasing infarct volume and improving neurological outcomes [172, 173]

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After 72 weeks, tirzepatide users lost 20.2% of baseline weight versus 13.7% with semaglutide (a 47% greater relative reduction)

Mechanism-focused studies may include receptor-pathway assays, biomarker panels, gene-expression analysis, protein-expression studies, cell-viability controls, migration assays, metabolic marker analysis, or stability testing