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Indeed metformin inhibits the mitochondrial oxidative phosphorylation complex I, leading to increased cellular AMP levels and subsequent stimulation of AMPK, an enzyme that plays key roles in the regulation of cellular energy homeostatis

It also reduces the production of inflammatory cytokines, chemokines, and the infiltration of immune cells in tissues, resulting in a broad range of neuroprotective and anti-inflammatory effects

2017;32(suppl 1):703

10.1016/j.cell.2016.12.039 286 VettoreL.WestbrookR

McGuire, M.D., and Racheal Oladimeji Scientists from TriNetX LCC, University of Virginia and Virginia State University This research was funded by: C

Newer compounds may attempt to influence several pathways at once