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(Source: ASMBS, June 2025) A 2026 network meta-analysis of randomized controlled trials (30 trials, 20,015 patients) found metabolic/bariatric surgery achieved significantly greater reductions than GLP-1 receptor agonists in total weight loss (10.3 percentage points), BMI (4.5 kg/m), body weight (11.7 kg), waist circumference (12.6 cm), and HbA1c (0.5%) at under 104 weeks
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GH/IGF-1 activity is linked with collagen and tissue maintenance
Free radicals are widely thought of as the evil force behind premature aging and antioxidants as the cure-all
This triple mechanism distinguishes it from existing agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist)
