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While the cells of the hepatic parenchyma have the flexibility to adapt to changing physiological demands with reversible functional and morphological alterations, sufficient stress, or noxious stimuli may lead to inability to maintain homeostasis and adverse cellular adaptations

Evolutionary preservation is notably observed in the catalytic domain, characterized by a Cys-Gly-Pro-Cys sequence maintaining redox function across taxa (18)

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Soliman, A