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The large 2025 JACC meta-analysis of 99,599 patients found consistent MACE reduction regardless of whether patients had diabetes, obesity, CKD, or heart failure

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Prior to the identification of BAP1- inactivation in these tumors, they were thought to be in the Spitz category, and often designated as halo Spitz nevi [82] or atypical Spitz tumors [78, 83]

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