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SURMOUNT-1 showed substantial average weight reductions across doses, with the largest at 15 mg, alongside lifestyle support

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The mechanism is not fully understood but may involve immune system activation triggered by the medication itself, changes in metabolic state during rapid weight loss, or interaction with other medications you are taking

However, certain individuals, such as those with pancreatitis, type 1 diabetes, or specific endocrine disorders, should avoid Ozempic usage due to potential adverse effects

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These typically improve within a few weeks as your body adjusts