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It has been assessed in clinical trials by Merrion Pharma as an oral solid-dosage form (GIPET TM ) for enhancing the absorption of Biopharmaceutical Class System III small molecules such as zoledronic acid and alendronate and macromolecules including insulin, desmopressin, and antisense oligonucleotides (Leonard et al., 2006)
Consistent with these effects, the mRNA expression of genes involved in -oxidation was compensatorily up-regulated in the d-carnitine group
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