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In the USA, more than 40% of adults are obese, with projections indicating that one in two people will be affected by 2030 (refs

weight loss (Phase 2/3 peak) | ~15% | ~22% | ~24% | | FDA Status | Approved (Wegovy, Ozempic) | Approved (Zepbound, Mounjaro) | Phase 3 (2026) | | Dosing frequency | Weekly | Weekly | Weekly | The additional glucagon receptor agonism is believed to be responsible for retatrutide's greater metabolic rate increase and enhanced fat oxidation compared to dual agonists

[1] Importance of Titration Gradual dose escalation is critical to balancing efficacy and tolerability

British Association of Dermatologists

Comparing Common Side Effects Know this first: As both drugs are GLP-1 agonists and work in almost the same way, side effects tend to be pretty similar overall