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Role of GLP analogs (and alternatives) in type 2 diabetes: The goal of drug therapy is generally to keep hemoglobin A1C 9% or if glycemic control is inadequate with a combination of the above-mentioned drugs

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The mechanism is that GLP-1 exerts its glucagon inhibitory effect in human pancreatic islets through an intrinsic (non-paracrine) PKA-dependent effect mediated by the activation of the few GLP-1Rs present in the plasma membrane of -cells, which ultimately inhibits P/Q-type Ca2+ channels ( in vivo ( GLP-1R is present not only in -cells and -cells, but also in -cells