50,51 DDIs with Narrow Therapeutic Index Drugs Other clinical studies on DDIs have investigated the delayed gastric emptying effect of GLP-1 RA on the pharmacokinetics of drugs with narrow therapeutic index (Table 5)
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doi: 10.1016/j.tice.2025.103305 92 ZhangCZhuWMengQLianNWuJLiuBet al
The rats received pentadecapeptide BPC 157 (0.16 g/ml) or nothing in the drinking water (12.0 ml/rat) until the sacrifice or once daily, intraperitoneally BPC 157 10.0 g/kg, 10.0 ng/kg, or saline (5.0 ml/kg b.w.)
Safety, Monitoring, and Contraindications Because Tesofensine influences norepinephrine and dopamine, it requires careful cardiovascular and neurological monitoring