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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program

The mTOR is a serine/threonine kinase that responds to nutrients and hormonal signals [102-104]

And it is precisely here that new evidence is prompting caution

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You can also talk with your clinician about how hormone replacement therapy (HRT) may help with weight gain