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Research models reveal that senescent cells accumulate with aging and in response to various stressors, secreting inflammatory factors known as the senescence-associated secretory phenotype (SASP) that promotes chronic inflammation and can induce senescence in normal cells

PMID 18258626

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Continuous, multi-month use is widely discouraged because of progressive insulin resistance, organ-growth concerns, and IGF-1 receptor desensitization

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Cycling protocols of four to six weeks on, four to six weeks off align with the biology of connective tissue repair and represent a conservative default in the absence of long-term human safety data