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These may include nausea, decreased appetite, vomiting, constipation, diarrhea, bloating, or abdominal discomfort
Such a strategy has been demonstrated in the case of cholangiocarcinoma, where IDH1 mutations resulted in the production of the oncometabolite 2-hydroxyglutarate, leading to epigenetic alterations and changes in the expression of key genes involved in cell differentiation and survival [202]
Independent purity verification is particularly critical for dual-receptor agonist peptides where structural integrity determines receptor binding specificity and clinical activity
doi: 10.1186/s13098-024-01301-3
Open Medicine, 18 (1), Article 20230692
