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Most side effects are mild and involve digestive issues such as nausea, constipation, diarrhea, abdominal pain, bloating, gas, heartburn, headache, fatigue, dizziness, runny nose and sore throat

Agerelated declines of 13 % per year in GH, melatonin, and cortisol further underscore the need for targeted interventions

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Conclusion GLP-1 RAs are an important class of glucose-lowering drugs

Cycle 8-12 weeks on, 4-8 weeks off

Keep behavioral targets such as protein at meals and consistent movement because supplements work best when supported by lifestyle changes