glp-1 and nad receptor agonists next-generation metabolic hormone therapies in chronic kidney disease Why NAD+ and GLP-1s Are

Stimulant / Irritant Laxatives Examples: Senna, Bisacodyl, Castor oil Mechanism: Stimulate enteric nerves increase peristalsis Uses: Short-term constipation, bowel prep Adverse Effects: Abdominal cramps, electrolyte imbalance, melanosis coli (long-term senna use) 4

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Lyophilised format for stability and storage

It is primarily driven by the development of hypertrophy in the afferent arteriole, which compromises autoregulation and facilitates heightened transmission of systemic blood pressure to the glomerulus

Insulin is a peptide with decades of research behind it

(If the patient already has central access, you can give D20W or D50W via central access