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& Tsujimoto, G

Nausea, vomiting, diarrhoea and constipation may occur, particularly at higher doses or during dose increases as the body adjusts to treatment

In a clinical pharmacology study designed to evaluate the effects of duloxetine on various parameters, including blood pressure at supratherapeutic doses with an accelerated dose titration, there was evidence of increases in supine blood pressure at doses up to 200 mg twice daily

Patients with T2D new to insulin therapy may be considered good candidates for these mixtures

further studies are needed. Additionally, Ostrominski said more studies should be conducted analyzing other cardiometabolic outcomes with use of the medications as well as in other populations