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It activates GHS-R1a and CD36 receptors in cardiac tissue, with CD36 playing a key role in providing the myocardium with its major energy substrate, and agonistic CD36 binding protecting against myocardial damage and dysfunction by ischaemia/reperfusion with mice deficient for CD36 showing complete loss of GHRP-6-mediated cardioprotection, confirming CD36 as an essential receptor for its cardiac effects

RushAJTrivediMHWisniewskiSRNierenbergAAStewartJWWardenDet al

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Table 3 summarizes RCTs of the dual and triple GLP1-RA use in obesity

If a dose is missed , the patient should take it as soon as possible if there are under three days (72 hours) after the scheduled dose