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Mmut p.L690Ins/p.L690Ins mice exhibited clinical signs of MMA within the first few weeks of life, and severe disease seemed to be precipitated following a transition to solid chow after weaning that was accompanied by a marked increase in methylmalonic acid

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For individuals with BMI above 40 or 50, the difference between 20% and 28% weight loss can be the difference between still being classified as obese and reaching a healthy weight range