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At 1 year, in the cohort of 465 adults with obesity but without diabetes, mean percent change in body weight from baseline ranged from 12.3% to 16.2% in the MariTide group, compared with 2.5% for those assigned placebo in the treatment policy estimand (intention-to-treat approach)

In DMBA-induced rat mammary carcinomas, the combination of diazoxide and medroxyprogesterone acetate moderately increased the remission rate, but clearly shortened the remission duration

Cancer Res 70:814958

This can lead to severe pain, death of the surrounding intestinal tissues, and infection of the abdominal cavity (peritonitis)

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