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These results should be interpreted in light of study limitations, including the exclusion of patients who discontinued treatment early, non-randomized treatment allocation, unmeasured adherence to dietary and physical activity recommendations, and variability in dose escalation and intensity
One key player in this response is posited to be MST1, a protein that increases its activity in the presence of oxidative stress
The silent problem Here is what makes this tricky
Dose The recommendation is to take between 3 and 5 g of creatine supplement each day
These symptoms are generally manageable, but for some, they can be severe enough to lead to discontinuation of the drug
