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Improved insulin sensitivity allows the body to more effectively utilize stored fat for energy rather than promoting continued fat accumulation

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The Bottom Line May 2026 Status Compounded semaglutide remains legal in May 2026 through 503A patient-specific compounding when prepared by licensed pharmacies under valid prescriptions with documented clinical rationale

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While semaglutide activates only the GLP-1 receptor, tirzepatide simultaneously activates both GLP-1 and GIP receptorsa distinction that translates into measurably stronger weight loss outcomes for many patients seeking precision-matched therapy

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