Epigenetic basis of sensitization to stress, affective episodes, and stimulants: implications for illness progression and prevention
Presented for research literature review only Kostopoulos VK et al
According to Bonaca and colleagues, improved blood flow translates to enhanced quality of life, demonstrated by the 2025 results of the STRIDE trial, in which semaglutide significantly increased walking distance and improved function in patients with peripheral arterial disease and type 2 diabetes
Semaglutide is a GLP-1 receptor agonist while tirzepatide activates both GIP and GLP-1 receptors, which can lead to larger average weight loss in some trials
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For example, a patient might use phentermine to kickstart their weight loss, then switch to a GLP-1 medication for long-term maintenance