In the present study, we investigated the protective effects and regulatory mechanism of GLP-1RAs on Ang II-induced VSMC proliferation and migration and Pi-induced VSMC calcification
The tubular protective effects appeared to be associated with the counteraction of PPAR deterioration, resulting in a maintenance of FAO, a decrease of intracellular accumulation of undigested FFAs, and attenuation of disease developmental factors including oxidative stress, apoptosis, and NFB activation (Figure 2)
doi: 10.1210/jc.2003-031403 18 HanF.HouN.LiuY.HuangN.PanR.ZhangX.et al
Our metabolomics data revealed that one-carbon metabolism in NALM-6 and SEM cells responded differently to MR (Figure 3B)
Furthermore, some were these drugs were associated with potential undesirable effects, such as the risk of heart failure or fractures (complications that are especially prevalent in patients with CKD), this is the case of thiazolidinediones, and the use of sulfonylureas and insulin are associated with weight gain or the risk of hypoglycemia
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