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selective NNMT inhibitors such as 5-Amino-1MQ are prominent tool compounds for target validation [2,8,9]
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If left untreated, severe vitamin B12 deficiency can lead to complications such as megaloblastic anemia, nerve damage, and neurological disorders
Inhibiting an endogenous metabolic enzyme can create effects beyond the intended experimental target, particularly when human exposure and long-term safety have not been established
Hematocrit, reticulocyte count, vitamin B 12, folate and iron levels should be obtained prior to treatment
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