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Caffeine, artificial sweeteners, and carbonated beverages (such as soda and even sparkling water ) can worsen gas and gastrointestinal distress

[Melatonin and depression] [PMID: 18683351] Laboratory literature summary: [Melatonin and depression]

Zieminska E, Toczylowska B, Diamandakis D, Hilgier W, Filipkowski RK, Polowy R, Orzel J, Gorka M, Lazarewicz JW

Ghrelin receptor agonists are understood to partially antagonize somatostatin's inhibitory influence on GH release, thereby reducing the "brake" on pituitary GH output

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this effect is almost immediate when you start Wegovy