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This hypothesis is also supported by our HIF-1 knockdown experiments, in which GLP-1R signalling-induced gene expression and metabolic adaptations were only partially perturbed, pointing to a possible involvement of additional transcriptional factors

"Copper complexes of glycyl-histidyl-lysine and two of its synthetic analogues: chemical behaviour and biological activity"

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doi: 10.1126/science.8134839 255 NelsonG.WordsworthJ.WangC.JurkD.LawlessC.Martin-RuizC.et al

Further research is needed to understand the effects of GHS on physiology

Its small size may support skin penetration, although this also depends heavily on the overall formulation and delivery system