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In tolerance assay, at 42 h after the end of conditioning regimen, shorter preconvulsive latencies than in healthy (non-diazepam conditioned) mice following isoniazid (800 mg/kg i.p.) (as hallmark of tolerance) were observed if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark)
Gromada, J., Holst, J
Nessuna mortalit attribuibile al peptide stata riportata negli studi animali pubblicati, anche a dosi molto superiori alle dosi efficaci (fino a 10 mg/kg)
These laboratory investigations remain focused on understanding molecular mechanisms and biological pathways rather than therapeutic outcomes
84 In this case-control study, which included 694 newly diagnosed patients and 708 controls, it was discovered that cruciferous vegetable consumption was associated with a 29% lower chance of developing bladder cancer
doi: 10.3390/ijms21030950 11 HannaMJaquaENguyenVClayJ
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