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But these were different trials, different populations, and different primary endpoints

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Mitochondrial-Nuclear Communication: Under conditions of metabolic stress or exercise, MOTS-c translocates to the nucleus, where it regulates the expression of nuclear genes associated with stress adaptation and homeostasis

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Therefore, various mechanisms for the hypopigmentary effect of Glutathione and Vitamin C have been proposed, with inhibition of tyrosinase being the most important