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Hippocampal salt-inducible Kinase 2 plays a role in depression via the CREB-regulated transcription coactivator 1-cAMP response element binding-brain-derived neurotrophic factor pathway

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Whilst there is a range of possibilities that would require large-scale investigation, the authors also hypothesize that these discrepancies arise as women are less likely to have insulin abnormalities and are less susceptible to its detrimental effects

rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase

it relies on an algorithm (Ferenci score) that takes into account clinical, genetic and biochemical findings

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