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If retatrutide gains adult approval in 2026 or 2027 (Phase 3 results from the TRIUMPH program are expected in 2025 to 2026), an adolescent trial could begin enrollment by 2028 at the earliest, with results by 2030

Specifically, ICER indicated a benchmark annual price range for semaglutide of between $7,500 to $9,800 would make the product cost-effective

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Semaglutide is contraindicated in patients with a personal or family history of certain types of thyroid cancer, specifically thyroid C-cell tumors such as medullary thyroid carcinoma (MTC), or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)

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