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Salicylic acid (SA), a key endogenous signaling molecule in plant immunity, mediates several defense mechanisms, including the activation of SAR, the induction of disease resistance gene expression, the strengthening of physical defense barriers, the activation of antioxidant defense systems, and the promotion of chitinase synthesis, which collectively contribute to the effective defense of plants against pathogens [12]

Although the contribution of dietary methionine excess (which increases folate, vitamin B 6 , and vitamin B 12 requirements) has not been clinically assessed, folate deficiency (associated or not with the thermolabile MTHFR mutation) and vitamin B 6 deficiency (associated or not with heterozygosity for CBS defects) could largely account for this increased risk of hyperhomocysteinemia-related cardiovascular disease

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