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This synergy makes the combination valuable for research models requiring substantial GH axis activation

Local formulary policies may also restrict access despite national guidance

Conversely, GI side effects with GLP-1 RAs or mild itching with THR- agonists could lead to discontinuation if not proactively managed through dose adjustments and patient education [52]

What is my long-term plan if I decide to discontinue GLP-1 therapy

In the brain, it activates receptors in the hypothalamus that reduce hunger and increase the feeling of fullness after eating