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The predominantly alpha-helical C-terminal domain is involved with the binding of hydrophobic substrates (such as hydrophobic portions of xenobiotics)

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Additionally, the upregulation of inflammation-related genes, such as IL-6 and TNF-, is associated with the pathological state of depression, suggesting that immune responses play a critical role in its pathogenesis [365, 366]

had 180 days of recorded medical history before and 720 days after the index date

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