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A 2001 Cochrane review and meta-analysis based on three RCTs concluded that magnesium was more effective than placebo to provide pain relief in dysmenorrhoea

and a recent intravenous safety pilot involved just two healthy adults

Pregnant or breastfeeding women are also advised against taking lipotropic injections, as the safety of these treatments during pregnancy and lactation has not been conclusively established

Actual timing depends on hydration status, sleep, stress, nutrition, and individual response

In these cases, B12 replacement may need to continue for an extended period or even lifelong

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