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This complexity underscores the need for stage-specific interventions: acute mitochondrial injury may respond to antioxidants or metabolic substrates, while advanced disease may require reprogramming of cellular bioenergetics
The combined treatment demonstrated significantly greater efficacy than standard-dose pregabalin or acetyl-l-carnitine alone, in terms of both pain symptoms measured by improvement on the VAS score (+12.8%) and neurosensory symptoms measured by the DN4 tool (+22%)
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A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects
Quantitative assay of free and total carnitine using tandem mass spectrometry
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In addition, long-term use of GLP-1RAs may also have potential safety risks, such as pancreatitis (Shetty et al., 2022) and thyroid diseases (Bezin et al., 2023), which require continuous monitoring and evaluation
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