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Two weeks following the final immunization, we employed the ex vivo Mycobacterial Growth Inhibition Assay (MGIA) as a surrogate of protective efficacy ( Figure 3 )
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This framework allows qualified medical providers to offer peptide therapies like MOTS-C to patients on a case-by-case basis, guided by clinical judgment and the latest available evidence
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Both the BCG-vaccinated group and the metE-AddaS03 protein-adjuvant group significantly inhibited mycobacterial growth compared to the unvaccinated group (p = 0.0001 and p = 0.01, respectively
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