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Research approaches include clinical studies of dialysis patients, animal models of chronic kidney disease (5/6 nephrectomy, adenine-induced nephropathy), and studies of isolated renal tubular cells

Nowicka P, Santoro N, Liu H, et al

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OS primarily affects three key mechanisms: (1) up-regulation of Na/K-ATPase, (2) increases water permeability while simultaneously reducing the protein reflection coefficient through the peritoneal barrier, and (3) stimulation of angiotensin-induced aldosterone secretion (137)

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