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Due to a small change in the molecule, the drug lasts for weeks instead of minutes in our bodies

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This supports mechanistic studies into receptor trafficking, drug binding, and signaling particularly in immunometabolic areas like pancreatic islets and inflamed adipose tissue

However, this increased efficacy comes with a trade-off: more pronounced gastrointestinal side effects, especially at the higher 15 mg dose

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In the phase 2 obesity trial reported in the New England Journal of Medicine , pancreatitis was monitored as a pre-specified safety endpoint