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When R-spondin 2 was added to explant cultures from wildtype mice, the number of outer hair cells decreased modestly, further indicating that R-spondin 2 has the opposite effect of -catenin activation in the developing cochlea and do not appear to potentiate canonical Wnt signaling to increase the number of hair cells (Jacques et al., 2012
Daily subcutaneous or intramuscular injection, ~300-500 mcg/day in standard use
and Edward DAlessandro, Jr
doi:10.1089/thy.2009.0200
S., Brcic, L., & Sever, M
The peptide also influences pain receptors and circadian rhythms
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