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Setting realistic goals: Define specific objectives (pain reduction, return to specific activities, healing verified on imaging) rather than vague "feel better." Understand realistic timeline (weeks for soft tissue, months for bone, months to years for cartilage) preventing premature disappointment

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As Pickart's research group documented: "GHK stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts" (Pickart et al., 2015)

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