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The amount and type of melanin a person produces are influenced by genetics, environmental factors, and exposure to sunlight

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Mol.Nutr.Food Res 2008;5 Weisberg, S

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However, even severe PCO may not be considered clinically relevant if it is present in a patient whose vision is already impaired for other reasons such as age-related macular degeneration or glaucoma (103, 104)