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Interestingly, the neural circuits responsible for the metabolic effects of GLP-1R agonism may be distinct from those mediating nausea or malaise (Huang et al., 2024), suggesting that future therapies could be tailored to preserve metabolic benefits while minimizing gastrointestinal side effects
GLP-1 was initially discovered for its ability to enhance glucose-stimulated insulin secretion (GSIS) (Kreymann et al., 1987
Sberg S, Sandholt CH, Jespersen NZ, et al
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