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Since estrogen decline is associated with increased inflammation, this effect may be especially beneficial for perimenopausal and menopausal women

ClinicalTrials.gov search: retatrutide.

In the absence of evidence from RCTs, real-world studies on hard outcomes have compared several classes of glucose-lowering medications, including GLP-1RA, dipeptidyl-peptidase 4 inhibitors (DPP-4i), and sodium glucose cotransporter-2 inhibitors (SGLT2i)

It is important to note that all STEP trials were industry funded, which should be considered when interpreting the results

Your PlexusDx provider can help determine whether your plateau results from inadequate dose escalation, the need for a different compound, or underlying genetic factors affecting medication response

Patients should report new or worsening anxiety, low mood, or suicidal thoughts to their GP immediately whilst taking GLP-1 medications