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This pathway depends on the enzyme cystathionine -synthase (CBS), together with adequate vitamin B6 status
Sources: Marcinkowska, A
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Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig
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